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Tadalafil belongs to the group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors, primarily used to treat erectile dysfunction (impotence) and benign prostatic hyperplasia (BPH). Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Benign prostatic hyperplasia, also called prostate enlargement, is the non-cancerous growth of the prostate gland.

Tadalafil contains ‘Tadalafil’, which works by relaxing the blood vessels in the penis; this allows the blood to flow into the penis when the person is sexually excited. Thereby, it helps to treat erectile dysfunction. Tadalafil relaxes the bladder and prostate muscles, thereby reducing enlarged prostate symptoms such as difficulty in urination and urgent need to urinate.

You are advised to take Tadalafil for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as headache, back pain, muscle pain, pain in the legs and arms, nasal congestion, indigestion, and facial flushing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Tadalafil if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension) or alpha-blockers; if you have heart problems or stroke, low blood pressure or uncontrolled high blood pressure. Tadalafil is not intended for use in women. Tadalafil may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Tadalafil should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side effects.

Read the label ofTadalafil Generic Sildenafil 5mg Tabletsto become a physician certified.

You are advised to take Tadalafil for as long as your doctor has prescribed it for you, depending on the condition being treated. In some cases, you may experience certain side effects, such as headache, back pain, muscle pain, muscle weakness or cramps, nausea, vomiting, and diarrhea. The most common side effects of Tadalafil are back pain, headache, muscle pain, muscle weakness or cramps, and back pain.

The information provided in the pages from the World Health Organization's Website about medicines hasbears serious risks, and the WHO Medical Bulletin has not taken any necessary action to assess the safety of medicines on WHO Web site. These medicines are indicated for the treatment of erectile dysfunction (ED) and benign prostatic hyperplasia (BPH).

Read the warning about taking medicines during pregnancy if you are using Tadalafil andbreast-feedingAwareness of the side effects of medicines and pregnancy can be very useful for preventing unwanted side effects. It is important to understand that medicines may harm your baby. This is because medicines may reduce the effectiveness of which you are a patient, medicines may delay the delivery of the baby, and medicines may interfere with the metabolism of some medicines. So before taking medicines for your baby, tell your doctor about your other medicines, as well as any other medicines you are taking. In particular, tell your doctor if you are taking:

divalproex
meth
phenobarbital
isocarboxazid
phenobarbital + phenytoin
phenytoin + oxcarbazepine
carbamazepine

Medicines that may be affected by the side effects of medicines used to treat your urinary tract may need medical treatment.

Patients using medicines used to treat your urinary tract should consult your doctor before taking any medicines. Your doctor will discuss with you the possible side effects of medicines used to treat your urinary tract. Medicines that may affect your kidneys may need medical treatment.

Read the warning about taking medicines during pregnancy if you are using Tadalafil and pregnancyAwareness of the side effects of medicines and pregnancy can be very useful for preventing unwanted side effects.

Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

for chest pain or use Rectogesic ointment?

• Nicorandil (Ikorel), used to treat angina

• Cimetidine, used to treat stomach or duodenal (peptic) ulcers

• Theophylline, used to treat asthma

• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

• Anti-fungals such as itraconazole and ketoconazole

• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

• Recreational drugs:- amyl nitrate (poppers)

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

Read available consultation questionnaire

What are the benefits and the potential risks of Tadalafil?

Tadalafil is a CYP2C8-based isomer of the drug, which can cause isomerocyst the isomers that you get with Tadalafil. The isomers are CYP2C8 isomers that you get when you are with other Tadalafil medicines. The major risk with is not clear but there is a possibility of increased drug interactions with these isomers.

There are several other possible risks which you should be aware of before you take Tadalafil. Please discuss any of the potential drug interactions with your GPs prior to starting and making your

or flomax recommendations in the “Is there any other medical information that the doctor should know?” in-closestion in your local

or health professional.

You should not take Tadalafil if you are taking one of the following 3 medicines or any other medicine :

• Tadalafil HCL (cialis) or Tadalafil (tadalafil) HCL (cialis)

• Any of the other medicines that you are taking:- Disopyramide, quinidine and procainamide- Telithromycin

• Use of a medicinal product (such as Tadalafil) in a medical emergency. A medical emergency may be a necessary condition for discharging your

or cardiovascular event. You should not take Tadalafil if you are taking any of the following products :-

• Any of the other products that you are taking:- Any of the other ingredients of any product you

as the name brandTadalafil is made with Tadalafil HCL and any of the other ingredients which are listed in the “Other ingredients” section of the drug interaction review (“Pack of medications”).

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

Ketoconazole, itraconazole (used to manage fungal infection)
Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

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Hypertension: In the UK, Cialis can increase the blood pressure by blocking an enzyme that regulates blood pressure. This can lead to symptoms like dizziness, headaches, or fainting--includinghypertension.

Liver Disease: Affected individuals should exercise caution when taking tadalafil, as it can cause a dangerous drop in blood pressure. Consult your doctor to determine whether this interaction is needed.

Stomach Bleeding: If you experience fever, diarrhea, or headache, seek medical attention immediately. This medication can cause a severe drop in blood pressure, especially during treatment with anticoagulants.